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The Lifestyle That Can Reverse Your Biological Age by 3 Years in Just Two Months

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Imagine reversing the clock—not just looking younger—but actually turning back your biological age at the cellular level.

According to a groundbreaking study, you can do just that.

Participants in a recent clinical trial reduced their biological clock by an average of 3.23 years in just eight weeks through diet and lifestyle changes.

This isn’t a dream. It’s a groundbreaking reality that reveals how a nutrient-dense diet, coupled with sound ancestral living principles, can rejuvenate your cells and effectively reverse the aging process.

The Study: An Ancestral Approach to Age Reversal

In a world where billions are spent each year on cosmetics, surgeries, and pills to look and feel younger, this pioneering study reveals that how you age is greatly impacted by what’s on your plate and the everyday lifestyle choices you make.

In a randomized control trial (RCT), forty-three healthy men aged 50-72 embarked on an eight-week journey involving dietary changes, improved sleep, exercise, relaxation, and supplementation with probiotics and phytonutrients. The control group continued with their usual habits. Using advanced genome-wide DNA methylation analysis, researchers measured biological age through the Horvath DNAmAge clock [1].

The results were remarkable. Participants in the treatment group experienced an average reduction of 1.96 years in their biological age, whereas the control group saw an increase of 1.27 years. This equates to a striking 3.23-year difference in biological age between the treated and non-treated participants in just two months [1]!

Nutrient Density, Carb Restriction & Fasting: Keys to Cellular Rejuvenation

Central to this age-defying intervention was a diet rich in nutrients that support methylation—a process that regulates gene expression by adding methyl groups to DNA. This diet included:

  • Folate, Vitamin A, Betaine, Vitamin C: Found in leafy greens, liver, and other nutrient-dense foods.
  • Mixed Polyphenolic Compounds: Such as curcumin from turmeric, EGCG from green tea, and rosmarinic acid from rosemary.
  • Nutrient-Dense Animal Proteins: Including liver and eggs, rich sources of choline—a powerful methylating nutrient found exclusively in animal foods.

The diet also restricted carbohydrates and included mild intermittent fasting to lower glycemic cycling.

Proper methylation supports healthy aging, but poor methylation can accelerate age-related decline.

This dietary intervention optimized methylation, promoting a biological environment where cellular youthfulness thrives [2].

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A Symphony of Healthy Lifestyle Habits

The study didn’t stop at diet.

Participants engaged in daily exercise, averaging 30 minutes of moderate to high-intensity activity. Exercise is known to improve cardiovascular health, metabolic function, and mental well-being, and it positively influences DNA methylation, contributing to a slower aging process [3].

They also practiced twice-daily breathing exercises to induce the Relaxation Response, mitigating the detrimental effects of stress on DNA methylation and aging. Chronic stress is linked to accelerated biological aging and increased disease risk [4].

Finally, participants were encouraged to get seven hours of sleep each night. Quality sleep is essential for overall health and well-being, and insufficient sleep is associated with adverse changes in DNA methylation and accelerated aging [5].

By incorporating exercise, relaxation techniques, and optimizing sleep, participants reduced stress levels and positively affected their methylation patterns.

The Probiotics That Maximize Methylation

The intervention included supplementation with probiotics and specific synergistic phytonutrients. Probiotics, like Lactobacillus plantarum used in this study, support gut health and produce natural folate in the gut. These beneficial bacteria have been shown to influence gene expression and contribute to healthier methylation patterns [6].

Phytonutrients, found in brightly colored fruits, vegetables, herbs, and spices, also benefit DNA methylation, supporting healthy gene expression and potentially reducing the risk of age-related diseases. Participants enjoyed a synergistic combination of polyphenols rather than a single isolated phytonutrient [7].

Safe On Your Plate… But Not in a Pill

The researchers designed the clinical trial to avoid supplementation with isolated compounds and methyl donor nutrients due to the serious long-term risks associated with synthetic vitamins and isolated compounds. For example:

  • B-PROOF Trial: A long-term follow-up on 2,524 participants found an increased risk of overall cancer and colorectal cancer with daily supplementation of folic acid and vitamin B12 [8].
  • Norwegian Trials: Reported increased cancer outcomes and all-cause mortality with daily supplementation of folic acid and vitamin B12 [9].

The Future of Age Reversal Can Be Found in Our Past

This groundbreaking study is a clarion call for a new era in health and wellness. By embracing a nutrient-dense, methylation-supportive diet and ancestral lifestyle changes, we can turn back our biological clocks—without the need for fancy (and harmful!) pills, procedures, and potions.

Unlock the secrets of ancestral living and take the first step towards a longer, healthier, and more vibrant life!

Methylating Meal Ideas

Here are a few meals featuring the age-defying focus foods mentioned in the study:

  • Pastured Chicken Livers over Organic Wilted Dandelion Greens with Balsamic Vinegar & Extra Virgin Olive Oil: Folate, vitamin A, betaine, choline, polyphenols. Iced Organic Green Tea with Lemon: EGCG, polyphenols, vitamin C.
  • Farm-Fresh Over-Medium Eggs Cooked in Grass-Fed Butter: Choline, vitamin A. Avocado with Flaky Sea Salt and Organic Blueberries: Polyphenols, vitamin C. Spiced Chai: Curcumin, polyphenols. Capsule L. Plantarum.
  • Rosemary-Roasted Turkey: Betaine, rosmarinic acid, vitamin B12. Roasted Sweet Potatoes with Grass-Fed Butter: Betaine, vitamin A.
  • Sautéed Grass-Fed Beef Liver & Onions: Vitamin A, vitamin B12, folate, choline. Buttery Cauliflower Mash: Vitamin C, vitamin A.
  • Grilled Grass-Fed Ribeye Steak: Betaine, vitamin B12, choline. Organic Sauteed Collard Greens with Onions & Extra Virgin Olive Oil: Folate, polyphenols, vitamin C.
  • Wild Salmon Salad with Beets, Beet Greens, and Arugula: Betaine, folate, vitamin B12.
    For this and more enlightening articles, be sure to visit our US Wellness Meats Discover Blog today!
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References

  1. Fitzgerald, K. N., et al. (2022). Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging.
  2. Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology, 14. 10.1186/gb-2013-14-10-r115
  3. Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016). Epigenetic mechanisms of longevity and aging. Cell, 166(4), 822-839. 10.1016/j.cell.2016.07.050
  4. Field, A. E., Robertson, N. A., Wang, T., Havas, A., Ideker, T., & Adams, P. D. (2018). DNA methylation clocks in aging: categories, causes, and consequences. Molecular Cell, 71(6), 882-895. 10.1016/j.molcel.2018.08.008
  5. Rando, T. A., & Chang, H. Y. (2012). Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell, 148(1-2), 46-57. 10.1016/j.cell.2012.01.003
  6. Vladimir K, Perišić MM, Štorga M, Mostashari A, Khanin R. Epigenetics insights from perceived facial aging. Clin Epigenetics. 2023 Nov 3;15(1):176. doi: 10.1186/s13148-023-01590-x. PMID: 37924108; PMCID: PMC10623707.
  7. Quach, A., Levine, M. E., Tanaka, T., Lu, A. T., Chen, B. H., Ferrucci, L., Ritz, B., Bandinelli, S., Neuhouser, M. L., Beasley, J. M., Snetselaar, L., Wallace, R. B., Tsao, P. S., Absher, D., Assimes, T. L., Stewart, J. D., Li, Y., Hou, L., Baccarelli, A. A., Whitsel, E. A., & Horvath, S. (2017). Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging, 9(2), 419-446. 10.18632/aging.101168
  8. White, A. J., et al. (2013). Recreational and household physical activity at different time points and DNA global methylation. Eur J Cancer.
  9. Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Menke A, Lange JF, Brückl T, et al. Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.
  10. Hariri, M., et al. (2015). A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes. Genes Nutr.
  11. Arora, I., Sharma, M., & Tollefsbol, T. O. (2019). Combinatorial epigenetics impact of polyphenols and phytochemicals in cancer prevention and therapy. International Journal of Molecular Sciences, 20(18), 4567.
  12. Oliai Araghi S, Kiefte-de Jong JC, van Dijk SC, Swart KM, van Laarhoven HW, van Schoor NM, de Groot LC, Lemmens V, Stricker BH, Uitterlinden AG, van der Velde N. Folic acid and vitamin B12 supplementation and the risk of cancer: long-term follow-up of the B vitamins for the prevention of osteoporotic fractures (B-PROOF) trial. Cancer Epidemiol Biomarkers Prev. 2019; 28:275–82. 10.1158/1055-9965.EPI-17-1198
  13. Ebbing M, Bønaa KH, Nygård O, Arnesen E, Ueland PM, Nordrehaug JE, Rasmussen K, Njølstad I, Refsum H, Nilsen DW, Tverdal A, Meyer K, Vollset SE. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA. 2009; 302:2119–26. 10.1001/jama.2009.1622
  14. Smith, J. (2024). Foods High in Betaine. Nutrition Insights Journal, 12(3), 45-52.