Here at the Sears Institute for Anti-Aging Medicine, I’ve been proving that Alzheimer’s is far from hopeless.And the research backs me up…Researchers at the Geffen School of Medicine at UCLA have documented the reversal of Alzheimer’s and coGnitive decline in more than 100 patients – utilizing many of the same protocols I use at my clinic.1These clinical trials prove what I’ve been telling my patients for years…
That the vast majority of Alzheimer’s cases are not genetic – and its effects can be reversed.Enough research has now been conducted to conclude that Alzheimer’s is most often the result of multiple environmental factors. And one of the most common of these factors is likely to be the toxic pesticides, insecticides and herbicides sprayed on the industrial crops you consume in your food every day.Researchers have known for years that two pesticides – organophosphate and carbamate, which are widely used on agricultural crops, as well as in gardens, homes, and offices – have a highly toxic effect on acetylcholine, a key neurotransmitter critical to brain function.2Age also causes acetylcholine levels to decline – but with the addition of environmental factoRs, the results can be devastating.You see, acetylcholine helps your brain cells communicate with each other. It’s involved in multiple brain functions, including sleep and muscle control.Most importantly, it’s also a neurotransmitter of memory. Your brain can’t store or access memories without acetylcholine, and you can’t restore acetylcholine levels without choline.Dozens of studies reveal acetylcholine is depleted in the brains of Alzheimer’s sufferers.3,4But the good news is you can replenish acetylcholine levels by boosting choline — an essential building block.This is one of the most powerful and proven ways to prevent dementia and protect your memorIes.
Replenish stores of choline naturally
One way to boost choline levels is to eat animal products like pastured eggs and grass-fed red meat and organ meats, like liver and kidneys. A 3-ounce serving of beef liver has 240 mg of choline. And a large egg has 141 mg.The problem is, in today’s world, it’s nearly impossible to eat enough choline-rich foods to satisfy your brain’s need for this essential nutrient. Your brain has a huge appetite for choline because you burn acetylcholine 24 hours a day, maintaining clear communication between your trillions of neurons.It’s vital that you replenish choline with food and supplements.On top of a choline-rich diet, I recommend 1,000 mg of choline citrate and 35 mg of its cousin, CDP choline. You can raise your daily choline intake up to 2,000 mg.In an MIT study, 95 people took 1,000 mg of CDP-choline or a pLacebo for three months.The patients with poor memory made gains in their recall. At 2,000 mg daily, patients also showed improved verbal memory.5
In a second study, 100 men and women between 50 and 85 with age-associated memory impairment took either CDP-choline or a placebo.After 12 weeks, patients given the CDP choline showed “significantly greater improvements” in a series of memory function tests compared to those who took the placebo.6
2 more ways to boost acetylcholine and protect your memories
There are other natural ways to replenish your brain’s supply of acetylcholine. Here’s what I suggest…
1. Acetyl-L-Carnitine
I’ve witnessed firsthand how this exceptional nutrient has restored razor-sharp thinking to many of my patients. And when you combine this powerful natural chemical with your choline cocktail, your body produces acetylcholine.Studies also show it has the power to repair aging hippocampi, which control learning, language, and memory in your brain.7The best sources of acetyl-L-Carnitine are grass-fed beef, poultry, fish, and dairy products. Fruits, vegetables, and grains contain relatively little.You can aLso get it in supplement form. I recommend taking 500 mg twice a day on an empty stomach.Look for a formula that has only L-Carnitine – not DL-carnitine. D-carnitine is synthetic, and it interferes with the action of natural L-Carnitine. Also, liquid ALC is more absorbable compared with powders and capsules.
2. Ginkgo biloba
This ancient herb is a natural brain booster and has been shown to inhibit age-related decline in acetylcholine receptors on neurons.
It also stimulates acetylcholine uptake in the hippocampus.8
I advise my patients to take 120 mg of Ginkgo biloba daily.
To Your Good Health,
Al Sears, MD, CNS
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References
1. Bredesen DE, et al. “Reversal of cognitive decline: 100 patients.“ J Alzheimers Dis Parkinsonism. 2018;Vol 8(5):450.
2. Lionetto M, et al. “Acetylcholinesterase as a biomarker in environmental and occupational medicine: new insights and future perspectives.” Biomed Res Int. 2013;Article ID 321213.
3. Francis P. “The interplay of neurotransmitters in Alzheimer’s disease.” CNS Spectr. 2005 Nov;10(11 Suppl 18):6-9.
4. Perry, E. “Acetylcholine and Alzheimer’s disease.” Brit J Psychiat. 1988;152(6):737-740.
5. Alvarez X, et al. “Citicoline improves memory performance in elderly subjects.” Meth Find Exp Clin Pharmacol. 1997;19: 201-210.
6. Nakazaki E, el al. “Citicoline and memory function in healthy older adults: a randomized, double-blind, placebo-controlled clinical trial.” J Nutr. 2021 Aug 7;151(8):2153-2160.
7. Taglialatela G, et al. “Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor.” Brain Res Dev Brain Res. Apr 1991; 59(2):221-30.
8. Commission E Monographs. American Botanical Council translation. Available at: http://cms.herbalgram.org/expandedE/GinkgoBilobaleafextract.html. Accessed on December 17, 2022.
