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Dial In Your Diet For Deeper, More Refreshing Sleep

phosphatidylserine, sleep, histamines, keto

By Kelley Herring

Each night millions of people in the US struggle to get a good night’s sleep. In fact, it is estimated that one in three people have brief symptoms of insomnia – with 10% of the population suffering from a chronic insomnia disorder, characterized by three nights of interrupted sleep per week for at least three months.

If you’ve ever struggled with insomnia, you know what a serious problem it can be.

Sleep loss increases your risk for depression and mood disturbances. It causes fatigue, poor memory and impaired focus. It reduces reaction time, leading to an increased risk of errors and accidents. It saps your motivation and energy. It promotes fat storage and weight gain. And it can even promote Alzheimer’s, high blood pressure and certain types of cancer.i

What’s more, insomnia promotes more rapid aging and degeneration at a cellular level – since it is in deep sleep that we repair and rebuild damaged cells.

Insomnia: Genetics and Environment

As a sufferer of insomnia myself, I know how much this disorder can take a toll on your health, happiness and quality of life.

Everything is a lot harder when you’re sleep deprived – whether it’s simply having the patience to help your child with their homework, the clarity of thought to do your job well, or the energy and stamina to exercise – insomnia can steal a lot of zest, productivity and peace from your life.

Like most desperate insomnia sufferers, I’ve tried just about everything to get a good night’s sleep. Going to bed at the same time each night and engaging in all of the suggested “sleep hygiene” techniques. A hot bath with magnesium, blue light blocking glasses after dark, an eye mask, soft socks, black-out curtains and the room dialed to the perfect temperature – and just about every natural supplement imaginable.

And like clockwork, I’d wake up after four or five hours of sleep, often unable to drift back to slumber.

Like most ailments, insomnia is a product of genetics and environment. In fact, estimates from twin studies show that insomnia is around 50% genetic, affecting more females more than males. This genetic predisposition coupled with environmental factors creates a susceptibility to insomnia.ii

What’s more, most genetic influence is on the type of insomnia where people have a hard time staying asleep, rather than difficulty falling asleep.iii

While we can’t change the genetic predispositions we have, we can work with them to create a better outcome.

And like most issues involving our health the primary way we can do this is through diet

plastic, cold and flu, sleep

Diet and Insomnia: What and When You Eat Matters

When it comes to the “environmental” piece of the insomnia puzzle, what you eat and when you eat can have a big impact on your sleep cycle.

The composition and timing of our meals impacts our circadian rhythms, microbiome, hormones and other biochemicals that impact the sleep-wake cycle.iv

As it relates to timing of eating, studies show that eating in the evening hours may cause in disruptions in healthy sleep patterns. And again, women seem to be especially vulnerable to these food-related disruptions in slumber.vvi

While more research is needed, restricting your eating to daylight hours is the pattern most-likely followed by our ancestors… and the one most biologically appropriate to produce a healthy sleep pattern.

Now let’s take a look at some of the dietary compounds that influence sleep…

Histamines & Overactive Mast Cells: Little-Known Causes of Sleep Disturbance

It may come as a surprise that even “healthy” foods – like sauerkraut, kefir, tomatoes and cured meats – can impair sleep for some people, due to their high levels of histamines.

Histamines influence a special type of immune cell called mast cells, which can activate in the early morning hours and promote wakefulness.vii This is one reason antihistamines (like Benadryl) are marketed as sleep aids – they can help you stay asleep by reducing mast cell activity.viii

Of course, antihistamines are not a healthy long-term solution for promoting sleep. Their regular use has been linked to memory loss and dementia, among other maladies.ix

While lower-histamine foods and mast-cell stabilizing supplements (like quercetin, vitamin C, bromelain and nettles) can help, recent research shows the keto diet may help to address the issue at its root.

A study published in Nutrition and Metabolism found that found that ketones have a powerful effect on stabilizing overactive mast cells, which contribute to allergic reactions and insomnia.x

What’s more, when your mast cells become dysregulated and overactive, sleep deprivation increases their overactivity. This compounds the problem and creates a vicious cycle.xi If you’ve ever been on the horrible ride of an “insomnia bender”, you know this draining cycle all too well!

food pyramid

Hacking Adenosine for Deeper, More Restorative Sleep

Another chemical that impacts sleep is adenosine. You might recognize this chemical as part of adenosine triphosphate (ATP) – the “energy currency” of life.

It turns out that adenosine is not only important for producing energy as part of ATP. It is also vital for sleep regulation, as adenosine forms a unique link between cellular energy and neuron activity, impacting the quality of our sleep.xii

Dr. Michael Breus, Ph.D., a clinical psychologist with a specialty in sleep disorders, says:

Adenosine builds up in the body throughout the day and contributes to our feeling increasingly less alert and wakeful as the day goes on, eventually helping to promote deeper slow-wave sleep at night. Studies show a ketogenic diet promotes adenosine activity in the body, helping to relax the nervous system, as well as reducing pain and inflammation — all of which can help improve sleep.”

Balance Blood Sugar and Cortisol to Promote Better Sleep

We’ve long known that not sleeping enough can reduce insulin sensitivity and increase hunger– promoting weight gain and setting the stage for diabetes and other chronic disease.xiiixiv

It seems that the association goes the other way too. High blood sugar and insulin spikes also impact the sleep cycle and boost the stress hormone, cortisol.xv

But when you are in ketosis consistently, cortisol levels decrease. This is because you are using ketones and fat for fuel, and have greater ability to spare your body’s sugar stores (glycogen).

Due to this metabolic switch, you don’t require as much cortisol to promote an increase in blood sugar that your body uses for energy. For those whose insomnia is driven by cortisol, the ketogenic diet may help overall cortisol levels to level out, therefore preventing the hormonal surges that keep you from falling – or staying – asleep.

Sleep More Soundly and Feel More Energetic During the Day

Of course, having balanced blood sugar – instead of blood sugar spikes and crashes – will naturally help you feel more energetic during the day.

A study published in the journal, Nutrients, found that a very low-calorie keto diet significantly reduced daytime sleepiness in a group of obese patients.

Another study, published in Epilepsia, found that children with epilepsy who followed a keto diet slept better, experienced a higher proportion of REM sleep, and felt less sleepy during the day — all of which improved their overall quality of life.xvi

Keto Insomnia Warning: It May Get Worse Before It Gets Better

Interestingly, if you want the benefits of the keto diet for sleep, you may need to be willing to accept some “keto insomnia” when first acclimating to the diet.

In fact, many people report a worsening of sleep patterns before improvement, as the body makes the metabolic switch from “sugar-burner” to “fat-burner”. This seems to be due to an increase in the stress hormone cortisol as the body adapts to burning fat for fuel. Once the body adapts, overall cortisol levels decrease.xvii

A study from the Medical University of South Carolina (MUSC) followed six morbidly obese teens who spent four months on a keto diet. While all showed lower levels of REM sleep (dreaming sleep) and excessive slow-wave (deep) sleep at the beginning of the experiment (indicating worse sleep), the reverse was true at the end of the study. xviii

Of course, there are other hormones and chemicals relating to sleep quality and duration (such as melatonin, serotonin, GABA, tryptophan, etc.), and certain compounds like caffeine and alcohol that can impair sleep. Stress levels, light exposure in your eyes and seasonal changes can also impact your sleep duration and quality.

For me, a low-histamine ketogenic diet has been a tremendous help for my night waking. I find that when I am following a ketogenic diet, I sleep without interruption, dream more and wake up feeling refreshed.

Do you struggle with insomnia? If so, have you tried the keto diet, and have you found it to be helpful?

Visit our Discover Blog for more articles from Kelley Herring.

kelley herring


Kelley Herring is the author of the brand new book Keto Breads – which includes more information you need to know about why it is so important to avoid wheat and grains in your diet, plus how to use healthy replacements for these foods to create all the breads you love… without the gluten, carbs and health-harming effects. Click here to learn more about Keto Breads

Sources & References

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ii Lind MJ1, Aggen SH1, Kirkpatrick RM1, Kendler KS1,2, Amstadter AB1,2.A Longitudinal Twin Study of Insomnia Symptoms in Adults.Sleep. 2015 Sep 1;38(9):1423-30. doi: 10.5665/sleep.4982.

iii Drake CL1, Friedman NP, Wright KP Jr, Roth T.Sleep reactivity and insomnia: genetic and environmental influences.Sleep. 2011 Sep 1;34(9):1179-88. doi: 10.5665/SLEEP.1234.

iv Jiang P1, Turek FW2.Timing of meals: when is as critical as what and how much.Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E369-E380. doi: 10.1152/ajpendo.00295.2016. Epub 2017 Jan 31.

v Crispim CA; Zimberg IZ; dos Reis BG; Diniz RM; Tufik S; de Mello MT. Relationship between food intake and sleep pattern in healthy individuals. J Clin Sleep Med 2011;7(6):659-664.

vi Yahia N1, Brown C2, Potter S3, Szymanski H3, Smith K3, Pringle L3, Herman C3, Uribe M3, Fu Z4, Chung M4, Geliebter A5,6,7.Night eating syndrome and its association with weight status, physical activity, eating habits, smoking status, and sleep patterns among college students.Eat Weight Disord. 2017 Sep;22(3):421-433. doi: 10.1007/s40519-017-0403-z. Epub 2017 Jun 2.

vii Friedman BS1, Steinberg SC, Meggs WJ, Kaliner MA, Frieri M, Metcalfe DD.Analysis of plasma histamine levels in patients with mast cell disorders.Am J Med. 1989 Dec;87(6):649-54.

viii Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019;17(3):427–433. doi:10.5217/ir.2018.00152

ix Gray SL, Anderson ML, Dublin S, et al. Cumulative Use of Strong Anticholinergics and Incident DementiaA Prospective Cohort StudyJAMA Intern Med. 2015;175(3):401–407. doi:10.1001/jamainternmed.2014.7663

x Nakamura S1, Hisamura R1, Shimoda S2, Shibuya I3, Tsubota K4.Fasting mitigates immediate hypersensitivity: a pivotal role of endogenous D-beta-hydroxybutyrate.Nutr Metab (Lond). 2014 Aug 28;11:40. doi: 10.1186/1743-7075-11-40. eCollection 2014.

xi Christ P, Sowa AS, Froy O, Lorentz A. The Circadian Clock Drives Mast Cell Functions in Allergic Reactions. Front Immunol. 2018;9:1526. Published 2018 Jul 6. doi:10.3389/fimmu.2018.01526

xii Masino, S.A & Kawamura, M & Wasser, C & Wasser, C & Pomeroy, L & Ruskin, D. (2009). Adenosine, Ketogenic Diet and Epilepsy: The Emerging Therapeutic Relationship Between Metabolism and Brain Activity. Current neuropharmacology. 7. 257-68. 10.2174/157015909789152164.

xiii Shorter sleep duration is associated with decreased insulin sensitivity in healthy white men.

Wong PM, Manuck SB, DiNardo MM, Korytkowski M, Muldoon MF

Sleep. 2015 Feb 1; 38(2):223-31.

xiv Van Cauter E1, Holmback U, Knutson K, Leproult R, Miller A, Nedeltcheva A, Pannain S, Penev P, Tasali E, Spiegel K.Impact of sleep and sleep loss on neuroendocrine and metabolic function.Horm Res. 2007;67 Suppl 1:2-9. Epub 2007 Feb 15.

xv Vargas I1, Vgontzas AN2, Abelson JL3, Faghih RT4, Morales KH5, Perlis ML6.Altered ultradian cortisol rhythmicity as a potential neurobiologic substrate for chronic insomnia.Sleep Med Rev. 2018 Oct;41:234-243. doi: 10.1016/j.smrv.2018.03.003. Epub 2018 Mar 27.

xvi Hallböök T1, Lundgren J, Rosén I.Ketogenic diet improves sleep quality in children with therapy-resistant epilepsy.Epilepsia. 2007 Jan;48(1):59-65.

xvii Langfort J1, Pilis W, Zarzeczny R, Nazar K, Kaciuba-Uściłko H.Effect of low-carbohydrate-ketogenic diet on metabolic and hormonal responses to graded exercise in men.J Physiol Pharmacol. 1996 Jun;47(2):361-71.

xviii Willi SM1, Oexmann MJ, Wright NM, Collop NA, Key LL Jr.The effects of a high-protein, low-fat, ketogenic diet on adolescents with morbid obesity: body composition, blood chemistries, and sleep abnormalities.Pediatrics. 1998 Jan;101(1 Pt 1):61-7.