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Today I want to tell you about a new breakthrough in the treatment of Alzheimer’s disease.
This discovery doesn’t waste time trying to reduce toxic proteins in the brain. Instead, it reverses the damage caused by Alzheimer’s to restore memory.
This is groundbreaking.
For decades, drug companies and government agencies have spent billions of dollars developing drugs designed to wipe out the amyloid-beta plaques and tau tangles.
While it’s true that plaques and tangles are the hallmarks of this terrible, memory-robbing disease – they aren’t the root cause of Alzheimer’s. They’re symptoms.
So it’s not surprising that all their efforts have failed.
In fact, Alzheimer’s medications make things worse.1
The onLy thing these drugs – like Aricept, Exelon, Reminyl, and other so-called cholinesterase inhibitors – have achieved is to line Big Pharma’s pockets.
But now a team of researchers from the Buck Institute in California has taken a completely different tack.
Rather than trying to reduce toxic proteins in the brain, they are reversing the damage caused by Alzheimer’s to restore memory.
Their approach focuses on a protein called KIBRA. It got the name because it’s found both in the kidneys and the brain.
In a brand-new study published in The Journal of Clinical Investigation, Buck researchers revealed that KIBRA in the brain is found mostly in synapses.2 These connections between neurons allow memories to be formed and recalled.
They are the building blocks of memory.
KIBRA is necessary for synapses to make memories. And research shows that the brains of Alzheimer’s patients are deficient.
Low brain levels corresponded directly with the severity of dementia as well as higher levels of the toxic tau protein.
Using lab mice with a condition that mimics human Alzheimer’s, the scientists were stunned to discover that boosting KIBRA restored synaptic function – and reversed memory loss.
What Is KIBRA And Why Is It So Important To Reduce Memory Loss?
All the information in your brain is essentially stored in the way that your neurons communicate and connect with each other.
Every time you learn a new fact or make a new memory, your neurons have to adjust their connections to store this new information.3
KIBRA’s primary purpose is to help create AMPA receptors.
These are the main neurotransmitter receptors in your brain responsible for healthy brain function.
KIBRA also plays a major role in determining how many connections and varieties of connections your brain is capable of. That means it has a significant influence on your overall cognitive and learning abilities, as well as your memory.
Buck Institute scientists are now developing ways to boost KIBRA levels in Alzheimer’s patients.
But you don’t Need to wait for any “development.”
The good news is that there is already one well-known nutrient that increases KIBRA levels. I’m talking about butyrate. You’ve heard me talk about how butyrate helps improve gut health and prevent disease.
But this short-chain fatty acid is also a brain booster. Let me explain…
You see, KIBRA activity is slowed down by a class of enzymes called histone deacetylases (HDACs). Inhibiting HDACs can help boost KIBRA activity.
And butyrate is one of the strongest HDAC inhibitors out there.
Previous studies have already shown that butyrate alleviates neuroinflammation and improves memory and cognitive impairment while helping to prevent and treat stroke, depression, Parkinson’s, and Alzheimer’s.4
3 Easy Ways To Boost Your Butyrate
Butyrate is produced by your own gut bacteria when it ferments Dietary fibers. Here are three ways you can boost levels:
- Eat it directly. The best sources are foods made from the full-fat milk of animals that eat grass — cows, sheep, goats, and buffalo — where it’s found in the form of sodium butyrate. Include more full-fat cheddar, Camembert, and Parmesan cheese, cream, and whole-milk yogurt. But you’re unlikely to get enough from food to repair the damage of Alzheimer’s.
- Take a supplement. Studies show that low dosages (below 3.5 grams daily) of butyrate supplements are the most beneficial. However, excessive rates (above 7 grams daily) can be damaging. I suggest starting with 500 milligrams a day and building up to 3 or 4 grams over a period of four or five weeks.
You should always take butyrate with healthy fatty acids like omega-3 to replenish your cell membranes. - Help your body to make its own. The best way to boost butyrate is by adding more fermentable fiber into your diet. I recommend foods that contain the indigestible prebiotic plant fibers inulin and oligofructose.
You can find fermentable inulin and oligofructose in foods like asparagus, bananas, chicory root, garlic, Jerusalem artichoke, leeks, and onions.
I also recommend you take a resveratrol supplement. This plant antioxidant enhances connectivity in your synapses by increasing the number of AMPA receptors.
I recommend 100 mg per day of pure trans-resveratrol.
To Your Good Health,
Al Sears, MD, CNS
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References:
- Thambisetty M. “Manufacturers need to be more open about a dangerous Alzheimer’s drug side effect.” Nov 23, 2023. STATNews. https://www.statnews.com/2023/11/28/lecanemab-leqembi-aducanumab-donanemab-side-effects-aria-brain/. Accessed March 24, 2024.
- Kauwe G, et al. “KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.” J Clin Invest. 2024;134(3):e169064.
- Shepherd JD, Huganir RL. “The cell biology of synaptic plasticity: AMPA receptor trafficking.” Annu Rev Cell Dev Biol. 2007;23:613-43.
- Govindarajan N, et al. “Sodium butyrate improves memory function in an Alzheimer’s disease mouse model when administered at an advanced stage of disease progression.” J Alzheimers Dis. 2011;26(1):187-97.
